DNA nanorafts are a novel way to make artificial cells that function similarly to biological membranes, according to a study published in Nature Materials.
In response to particular chemical cues, DNA (deoxyribonucleic acid) nano-rafts, they are tiny, flat structures composed of DNA strands. It can be programmed to regulate the permeability and shape of cell membranes.
They can manipulate cell-like membranes in a controlled manner thanks to this ability.
• DNA Nanorafts' Attachment to Model Membranes: Giant Unilamellar Vesicles (GUVs) are a simplified representation of biological cell membranes.
• GUVs are useful for researching membrane behavior and transport mechanisms in synthetic biology because they are synthetic, cell-sized lipid membranes that closely resemble actual cell membranes.
• Reversibility and Shape Modification: When "unlocking" DNA strands are added, DNA nanorafts enlarge, changing the shape of the membrane.
• Enzymes, mechanical devices, and other techniques can initiate this unlocking. Adding "locking" DNA strands reverses the process and returns the structure to its initial state.
• For stability, locked nucleic acid (LNA) aids in holding DNA strands together.
• Scientists can precisely control artificial cell membranes through the use of controlled membrane manipulation.
• Cell Shaping: Synthetic cell membrane structure, which is necessary for cell migration, division, as well as communication, can be changed by nanorafts.
• Gatekeeping (Molecular Transport): They open transient membrane channels that let molecules flow through.
• Like the natural protein-based channels found in living cells, these channels can open and close as necessary.
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